Intravenous therapy for the treatment of syphilis



- Patented Feb. 1, 1939 I I 2,145,869

f;,., "UN TED STATES PATENT OFFICE INTRAVENOUS THERAPY FOR THE TREAT-LIENT OF SYIHILIS Donato Prez Garcia, Mexico, D. F., Mexico No Drawing.Application July 13, 1935, Serial No. 31,287

2 Claims. (Cl. 167-459) My invention relates to a composition and sysofchemically pure calcium and 4 grammes plus 'tem for the treatment ofneurosyphilis, and in '50 centigrammes of chemically pure glucosegeneral for the treatment of syphilis in any one therein. I then sealthe ampule in the usual of its stages. The system and composition aremanner with the proper precautions as to sterili- 5 radical in "thatthey make a definite progress in zation, such as are customary in theproduction '5 thetreatment of the disease. of ampules of this type.Approximately 15 cubic The system is based on the simultaneous usecentimeters of double distilled water may be of certain chemicals andtreatments which to added. some' extent have already been known to be Tomake use of the foregoing solution and subbeneficial in the treatment ofthe disease, although stances possible ,in the quantities mentioned, 10.not in association with each other or in the pro-' without fatalresults to the patient being treated, portions herein set forth. The useof these mathe patient must first be prepared to be able to "terials inthe proportions herein set forth canwithstand the injection, as it iswell known that 'not have a fatal toxic result because of the method thehuman body has a limit of resistance to inl5 I employ for preparing thepatient for their travenous injections of this type, beyond whichrecepti n. limit the injection is likely to have fatal results.

Through my discovery, the use of doses of I prepare'the patient bypreviously injecting a the materials in the quantity and proportionsquantity of insulin in such a way that this inherein set forth is madepossible, with the conjection may produce on him a hypoglucemic sequentbeneficial results. shock. This is for two purposes: to increase the 20The use of a glucose solution by intravenous antitoxin function of theorgans such as the liver injection is beneficial in the treatment ofneuroand kidneys, etc., in charge of such function, and syphills or ofsyphilis in general, but by itself further to give permeability to thenerve cells it can have no real value as a treatment for and all othersof the human body. As the antithese diseases. In my system of treatment,I toxic function is increased, larger quantities of 5 use as a vehiclefor the administration of remedial medicamental substances than the bodywould agents for the treatment of these diseases, a normally be able totolerate may be injected. glucose solution of with chemically pure Themost successful way of treating the body calcium chloride in theproportions of fifteen for diseases of the type herein mentioned is to30 cubic centimeters of glucose solution with about saturate theorganism with the medicaments 30 0.50 gramme of calcium chloride. I usethe foreused. Arsenic, mercury and bismuth, as Well as going quantityfor one intravenous injection. glucose and calcium chloride would betoxic in This compound can be mixed if desired, with the large dosesrequired to saturate the organism arsenical salts of the well knownNeo-Salvarsan of a patient in the ordinary maner of using and type, suchas Neo-Arspenemine, Neo-Diarse-' applying them by injection. With thissystem, 1101, etc. Likewise, the glucose solution may be they are nottoxic, and, therefore, larger quantiof 30% and may be injected inquantities I of ties than usual may be applied, either singly or fromten cubic centimeters up to twenty cubic in combination.

centimeters. The quantity of calcium chloride Prior to my invention ordiscovery thereof, 40 p fly n Pill; in t So ution of glucose mayhypertonic solutions of glucose have not been 40 vary from one-half toone gramme. employed for the treatment of syphilis. In my Thesolutionmay be prepared in the desired system, the glucose has two effects: itserves as strength within the limits above set forth and a vehicl aswell as a curative agent in and of P p in mp o lass or other convenientitself. It serves as a vehicle because in it are dis- 4'5 dosemeasurements. solved the other curative agents mentioned.

The dose in respect to the quantity of calcium The glucose in my formulaserves as a curative chloride varies according to the sensibility of theagent in the sense of curing the state of hypopatient for calcium. Thisis determined with the glicemia. As the quantity is larger than the fi sinjection, of the Small a ount, Subsequent one needed to isotonize theblood it also has a injections containing more according to therecurative effect because, due to being hypertonic, 5o sults. when theblood becomes hypotonic as a result In preparing the formula forpractical use, of the effect of the insulin, the quantity of the' I takean ampule of for instance somewhat more cristaloid of the bloodincreases in this way in than 15 cubic centimeters capacity, place onesuch manner thatdue to its high concentration gramme, 50 centigrammes ofchloride or gluconate tforces the other medicaments accompanying 55 itin the same solution, into all the cells of the system. Thus, glucose inthis sense serves two purposes, a chemical and a phyical one.

It is to be noted that glucose of the blood is increased at the momentit is necessary to increase it, and not before, as otherwise a patientleft with merely an injection of insulin might suffer seriousconsequences.

The compound prepared according to the formula of this invention,besides possessing its own beneficial properties may be used as aninjection in the manner prescribed, that is to say after preparation ofthe patient, to dissolve the arsenical salts of the Salvarsan type,which is commonly used for treatment of syphilis. Further, the presentcomposition, unlike the arseni cal salts mentioned, can be used at anytime without fear of its having undergone some decomposition that wouldrender it dangerous as often happens with the Salvarsan type oftreatment, the latter having to be used practically as soon as preparedto be absolutely safe. Also with the use of the solution of my inventionin the system described, larger quantities of arsenical salts I may besafely employed than would ordinarily be possible for the treatment ofthe patient. That is, instead of beginning with a dose of 0.15 gramme,there may be used to start 0.30 or 0.45

gramme.

It will thus be seen that I have provided a system for the beneficialtreatment of syphilis and kindred diseases that respond to the sametreatment, wherein the patient is first prepared for the reception ofintravenous injectionand then as a result of such preparation isinjected with a solution of glucose and calcium chlorideor calciumgluconate in a quantity thatwould ordinarily otherwise be fatal, butwhich in my system is exceedingly beneficial.

What I claim is: g

1. As a vehicle for the intravenous administration of remedial agents ofthe arsenical type, a composition containing in a aqueous glucosesolution, calcium chloride in the ratio of onesixth to one-third of theglucose present.

2. A medicinal composition for intravenous injection comprising 30 tocentigrammes of an arsenical useful in the treatment of syphilis in avehicle comprising a 30% aqueous glucose solution containing calciumchloride in the ratio of one-sixth to one-third of the glucose present.

DQNATO PEREZ GARCIA.

